bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. - Wikidata - awgldk - TriplyDB

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.

http://www.wikidata.org/entity/Q36368245

about

Caspase activation is required for terminal erythroid differentiation Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1 The Bcl-2 apoptotic switch in cancer development and therapy Harnessing the apoptotic programs in cancer stem-like cells Apoptosis: role in myeloid cell development Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions Bcl-xL prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.The Bcl-2 family: roles in cell survival and oncogenesis.Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice.Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.Apoptotic mechanisms in the control of erythropoiesis.Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins.CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner Delving deeper: MCL-1's contributions to normal and cancer biology.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members EPO receptor circuits for primary erythroblast survival Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival.Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts.BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis.Mesodermal and hematopoietic differentiation from ES and iPS cells.Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells.Mitochondria-mediated apoptosis in mammals.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Bcl-2 proteins in development, health, and disease of the hematopoietic system.The notch pathway positively regulates programmed cell death during erythroid differentiation.Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.G1-Cdk activity is required for both proliferation and viability of cytokine-dependent myeloid and erythroid cells.The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.FADD deficiency impairs early hematopoiesis in the bone marrow.

P2860

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P2860

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.

http://www.wikidata.org/entity/Q36368245

description

1999 nî lūn-bûn

@nan

1999年の論文

@ja

1999年学术文章

@wuu

1999年学术文章

@zh-cn

1999年学术文章

@zh-hans

1999年学术文章

@zh-my

1999年学术文章

@zh-sg

1999年學術文章

@yue

1999年學術文章

@zh

1999年學術文章

@zh-hant

name

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@ast

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@en

type

label

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@ast

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@en

prefLabel

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@ast

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@en

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P356

JEM.189.11.1691

P1433

Journal of Experimental Medicine

P1476

bcl-x prevents apoptotic cell ...... ytes at the end of maturation.

@en

P2093

Kimura T

http://www.w3.org/2001/XMLSchema#string

Motoyama N

http://www.w3.org/2001/XMLSchema#string

Nakano T

http://www.w3.org/2001/XMLSchema#string

Takahashi T

http://www.w3.org/2001/XMLSchema#string

Watanabe T

http://www.w3.org/2001/XMLSchema#string

P2860

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Apoptosis in the pathogenesis and treatment of disease

Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

The Bcl-2 protein family: arbiters of cell survival

P304

1691-1698

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scholarly article

P356

10.1084/JEM.189.11.1691

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11

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189

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P5875

12938547

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P698

10359572

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P921

apoptotic process

P932

2193080

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