about
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Somatic hypermutation of the AID transgene in B and non-B cellsUnique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosinesActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationUpdate on the hyper immunoglobulin M syndromesInaccurate DNA synthesis in cell extracts of yeast producing active human DNA polymerase iota.Human DNA polymerase iota promiscuous mismatch extension.Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.The RAG proteins in V(D)J recombination: more than just a nuclease.Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakRegulation of hypermutation by activation-induced cytidine deaminase phosphorylationMechanism and regulation of class switch recombinationAID and mismatch repair in antibody diversification.Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.Mismatch-mediated error prone repair at the immunoglobulin genes.Analysis of the Par2 modifier of pulmonary adenoma formation in mice.Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell linesThe translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.
P2860
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P2860
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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2000年學術文章
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2000年學術文章
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name
Error-prone candidates vie for somatic mutation
@ast
Error-prone candidates vie for somatic mutation
@en
type
label
Error-prone candidates vie for somatic mutation
@ast
Error-prone candidates vie for somatic mutation
@en
prefLabel
Error-prone candidates vie for somatic mutation
@ast
Error-prone candidates vie for somatic mutation
@en
P2093
P2860
P356
P1476
Error-prone candidates vie for somatic mutation
@en
P2093
M D Scharff
M F Goodman
V Poltoratsky
P2860
P304
P356
10.1084/JEM.192.10.F27
P407
P577
2000-11-01T00:00:00Z