Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally - Wikidata - awgldk - TriplyDB

Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

http://www.wikidata.org/entity/Q28592782

about

Two novel human and mouse DNA polymerases of the polX family The role of DNA polymerase activity in human non-homologous end joining Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.poliota, a remarkably error-prone human DNA polymerase Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis A new class of errant DNA polymerases provides candidates for somatic hypermutation.The reverse transcriptase model of somatic hypermutation Transcription, beta-like DNA polymerases and hypermutation Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification Somatic immunoglobulin hypermutation.AID and somatic hypermutation.Base excision repair in a network of defence and tolerance.DNA polymerases and somatic hypermutation of immunoglobulin genes MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Emerging links between hypermutation of antibody genes and DNA polymerases.AID and mismatch repair in antibody diversification.Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.DNA deamination in immunity.DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Error-prone candidates vie for somatic mutation Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.Translesion DNA synthesis in the context of cancer research.Targeting Gene Function in Germinal Center B Cells: A Practical Approach.Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

http://www.wikidata.org/entity/Q28592782

description

2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 2000

@ast

im Februar 2000 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2000/02/01)

@sk

vědecký článek publikovaný v roce 2000

@cs

wetenschappelijk artikel (gepubliceerd op 2000/02/01)

@nl

наукова стаття, опублікована в лютому 2000

@uk

name

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@ast

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@en

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@nl

type

label

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@ast

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@en

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@nl

prefLabel

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@ast

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@en

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@nl

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mice reconstituted with DNA po ...... mutate their Ig genes normally

@en

P2093

G. Esposito

http://www.w3.org/2001/XMLSchema#string

G. Texido

http://www.w3.org/2001/XMLSchema#string

H. Gu

http://www.w3.org/2001/XMLSchema#string

U. A. Betz

http://www.w3.org/2001/XMLSchema#string

U. Klein

http://www.w3.org/2001/XMLSchema#string

P2860

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Severe attenuation of the B cell immune response in Msh2-deficient mice

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

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1166–1171

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scholarly article

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3299467

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10.1073/PNAS.97.3.1166

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3

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97

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2000-02-01T00:00:00Z

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12658309

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10655502

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Polymerase (DNA directed), beta

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15557

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