Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor proteinGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseDistribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissuesTrafficking and proteolytic processing of APPCaveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor proteinFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinNeuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers.Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Trafficking to the apical and basolateral membranes in polarized epithelial cellsMint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generationExpression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cellsNovel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complexSystematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein.Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains.Genetic studies in Alzheimer's disease.Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B.A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.A sensitive and quantitative assay for measuring cleavage of presenilin substrates.Apical sorting of beta-secretase limits amyloid beta-peptide production.Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.Hierarchy of sorting signals in chimeras of intestinal lactase-phlorizin hydrolase and the influenza virus hemagglutinin.The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells.Basolateral sorting of the cation-dependent mannose 6-phosphate receptor in Madin-Darby canine kidney cells. Identification of a basolateral determinant unrelated to clathrin-coated pit localization signals.The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.Polarized apical targeting directed by the signal/anchor region of simian virus 5 hemagglutinin-neuraminidase.Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.Baculovirus-infected cells do not produce the amyloid peptide of Alzheimer's disease from its precursor.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
P2860
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P2860
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Polarized sorting of beta-amyl ...... ed by two independent signals.
@ast
Polarized sorting of beta-amyl ...... ed by two independent signals.
@en
type
label
Polarized sorting of beta-amyl ...... ed by two independent signals.
@ast
Polarized sorting of beta-amyl ...... ed by two independent signals.
@en
prefLabel
Polarized sorting of beta-amyl ...... ed by two independent signals.
@ast
Polarized sorting of beta-amyl ...... ed by two independent signals.
@en
P2093
P2860
P356
P1476
Polarized sorting of beta-amyl ...... ed by two independent signals.
@en
P2093
P2860
P304
P356
10.1083/JCB.128.4.537
P407
P577
1995-02-01T00:00:00Z