Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel
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The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockersCharacteristics of cocaine block of purified cardiac sarcoplasmic reticulum calcium release channels.Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channelsChannel blocking properties of a series of nicotinic cholinergic agonists.Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.Blockade of cardiac sarcoplasmic reticulum K+ channel by Ca2+: two-binding-site model of blockade.Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel.Dynamic ion-ion and water-ion interactions in ion channels.Energy transduction in the bacterial flagellar motor. Effects of load and pH.Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipersExtended dipolar chain model for ion channels: electrostriction effects and the translocational energy barrierDimensions of the narrow portion of a recombinant NMDA receptor channel.Electrostatic modeling of ion pores. II. Effects attributable to the membrane dipole potentialHow pore mouth charge distributions alter the permeability of transmembrane ionic channels.Large divalent cations and electrostatic potentials adjacent to membranes. Experimental results with hexamethonium.Effect of pore structure on energy barriers and applied voltage profiles. I. Symmetrical channels.Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.Agonists block currents through acetylcholine receptor channels.Some unexpected consequences of a simple physical mechanism for voltage-dependent gating in biological membranes.Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayersEffects of phospholipid surface charge on ion conduction in the K+ channel of sarcoplasmic reticulum.Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels.K⁺ conduction and Mg²⁺ blockade in a shaker Kv-channel single point mutant with an unusually high conductanceA cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels.Channel-mediated monovalent cation fluxes in isolated sarcoplasmic reticulum vesicles.An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.Single Na+ channels activated by veratridine and batrachotoxinDivalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels.On the interaction of bovine pancreatic trypsin inhibitor with maxi Ca(2+)-activated K+ channels. A model system for analysis of peptide-induced subconductance states.Effects of local anesthetics on single channel behavior of skeletal muscle calcium release channel.Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine.Blockade of a retinal cGMP-gated channel by polyaminesBlock of brain sodium channels by peptide mimetics of the isoleucine, phenylalanine, and methionine (IFM) motif from the inactivation gateKinetics of 9-aminoacridine block of single Na channels.Voltage-dependent blockade of muscle Na+ channels by guanidinium toxinsBlock of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines.Na+ block and permeation in a K+ channel of known structureProbing an open CFTR pore with organic anion blockersMechanism of cGMP-gated channel block by intracellular polyamines.Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltage
P2860
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P2860
Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
1982年學術文章
@zh
1982年學術文章
@zh-hant
name
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@ast
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@en
type
label
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@ast
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@en
prefLabel
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@ast
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@en
P2860
P356
P1476
Bis-quaternary ammonium blocke ...... coplasmic reticulum K+ channel
@en
P2093
P2860
P304
P356
10.1085/JGP.79.5.869
P577
1982-05-01T00:00:00Z