Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues
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Sodium channel molecular conformations and antiarrhythmic drug affinityMolecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of actionState-dependent trapping of flecainide in the cardiac sodium channelThe role of late I Na in development of cardiac arrhythmiasA novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic responseComparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineParameterization for In-Silico Modeling of Ion Channel Interactions with DrugsA computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythmsEngineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.Multiple modes of ryanodine receptor 2 inhibition by flecainide.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Requirement for chloride channel function during the hepatitis C virus life cycle.Pharmacogenomics in the treatment of epilepsy.Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide.Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons.Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations.Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.Inherited calcium channelopathies in the pathophysiology of arrhythmias.Pharmacogenetics of drug-induced arrhythmias.The sodium channel as a target for local anesthetic drugs.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels.Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.Use-Dependent Block of Human Cardiac Sodium Channels by GS967.
P2860
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P2860
Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Common molecular determinants ...... uaternary flecainide analogues
@ast
Common molecular determinants ...... uaternary flecainide analogues
@en
type
label
Common molecular determinants ...... uaternary flecainide analogues
@ast
Common molecular determinants ...... uaternary flecainide analogues
@en
prefLabel
Common molecular determinants ...... uaternary flecainide analogues
@ast
Common molecular determinants ...... uaternary flecainide analogues
@en
P2093
P2860
P356
P1476
Common molecular determinants ...... uaternary flecainide analogues
@en
P2093
Huajun Liu
Joshua Atkins
Robert S Kass
P2860
P304
P356
10.1085/JGP.20028723
P577
2003-03-01T00:00:00Z