Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.
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State-dependent trapping of flecainide in the cardiac sodium channelComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesProtective effects of antiarrhythmic agents against anoxic injury in CNS white matterFast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental studyUse-dependent inhibition of Na+ currents by benzocaine homologs.Distinct local anesthetic affinities in Na+ channel subtypesModification of cardiac Na+ channels by batrachotoxin: effects on gating, kinetics, and local anesthetic binding.Post-repolarization block of cardiac sodium channels by saxitoxin.Mathematical modeling of physiological systems: an essential tool for discovery.Characterization of cocaine-induced block of cardiac sodium channels.Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaineThe L-type calcium channel in the heart: the beat goes onCardiac sodium channel Markov model with temperature dependence and recovery from inactivationState-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsA quantitative description of QX222 blockade of sodium channels in squid axons.Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptorsUse-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes.Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axonsSodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers.Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells.Electrocardiographic interactions between pinacidil, a potassium channel opener and class I antiarrhythmic agents in guinea-pig isolated perfused heart.Electrophysiological effects of diprafenone, a dimethyl congener of propafenone on guinea-pig ventricular cells.Sodium channel inactivation: molecular determinants and modulation.Kinetics of rate-dependent slowing of intraventricular conduction by the class Ib antiarrhythmic agent tocainide in vivo.The virtual heart as a platform for screening drug cardiotoxicity.Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.Molecular action of lidocaine on the voltage sensors of sodium channelsCommon molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analoguesDevelopment of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, AntillatoxinThe value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysisTwo functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channelsModification of K+ channel-drug interactions by ancillary subunits.Computational approaches to understand cardiac electrophysiology and arrhythmias.Identification of Ikr kinetics and drug binding in native myocytes.Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction.
P2860
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P2860
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.
description
1984 nî lūn-bûn
@nan
1984 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1984 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
name
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@ast
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@en
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@nl
type
label
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@ast
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@en
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@nl
prefLabel
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@ast
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@en
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@nl
P2093
P2860
P1433
P1476
Mechanisms of use-dependent bl ...... embranes by local anesthetics.
@en
P2093
C F Starmer
H C Strauss
P2860
P356
10.1016/S0006-3495(84)83994-6
P407
P577
1984-07-01T00:00:00Z