about
Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction couplingFunctional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (alpha1S) expressing two complementary protein fragmentsIdentification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loopA component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine receptor alpha(1s) pore subunit.Endogenous cardiac Ca2+ channels do not overcome the E-C coupling defect in immortalized dysgenic muscle cells: evidence for a missing linkA carboxyl-terminal region important for the expression and targeting of the skeletal muscle dihydropyridine receptor.Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes.Recovery of Ca2+ current, charge movements, and Ca2+ transients in myotubes deficient in dihydropyridine receptor beta 1 subunit transfected with beta 1 cDNA.Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channelA malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channelsCa2+ current activation rate correlates with alpha 1 subunit density.Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit.Molecular origin of the L-type Ca2+ current of skeletal muscle myotubes selectively deficient in dihydropyridine receptor beta1a subunitDifferential regulation of skeletal muscle L-type Ca2+ current and excitation-contraction coupling by the dihydropyridine receptor beta subunit.Properties of Na+ currents conducted by a skeletal muscle L-type Ca2+ channel pore mutant (SkEIIIK).Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop.Triad formation: organization and function of the sarcoplasmic reticulum calcium release channel and triadin in normal and dysgenic muscle in vitro.Formation of triads without the dihydropyridine receptor alpha subunits in cell lines from dysgenic skeletal muscleContractions of dysgenic skeletal muscle triggered by a potentiated, endogenous calcium currentSingle calcium channel behavior in native skeletal muscle.Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes.Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channelPotentiation of the cardiac L-type Ca(2+) channel (alpha(1C)) by dihydropyridine agonist and strong depolarization occur via distinct mechanisms.Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.Impaired gating of an L-Type Ca(2+) channel carrying a mutation linked to malignant hyperthermia.The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry.Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.Molecular diversity of voltage-dependent calcium channel.Restoration of junctional tetrads in dysgenic myotubes by dihydropyridine receptor cDNA.The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.Endogenous calcium channels in human embryonic kidney (HEK293) cells.Relationship of calcium transients to calcium currents and charge movements in myotubes expressing skeletal and cardiac dihydropyridine receptors.Endogenous DHP-sensitive Ca(2+) channels in Pleurodeles oocytes.Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells.
P2860
Q24680364-7C789896-2449-4166-BD8D-C8762C9EEB4AQ24798316-00578229-94AC-4EF0-97B2-C1F514957D77Q28207968-1E3AFF96-998D-45A0-A2AF-1F11598030B3Q28365149-77132F41-E5A2-4663-97C8-CEC837F67303Q28588243-284F61A8-5BF8-42AF-B716-6684F553B402Q30868788-71EB1F61-2873-469B-9A06-2CDC2C42B11FQ32123389-DF66130E-E5AA-4D37-92B4-88C40C87B3E1Q33907194-BB1065D9-6E8C-45C7-AE6F-6B174B692271Q33915557-00DEB62C-BD49-434E-AA4B-26CB3EE6175CQ33922848-E891F3C4-8A5C-4E7C-B8EF-7A749D2DA133Q34040093-8EEF3431-9AEC-43F8-9E46-015321964AD1Q34041027-6AE98481-F3C5-4002-AEA5-0FB7EEFE55EFQ34168362-5969A77D-7682-4315-B2C4-27D573D4B381Q34170119-7872C2D6-BD03-42B9-A774-8E0D335CD3B4Q35577775-FE367260-B3A9-41B4-A32D-BD024C84CDE4Q35901193-8533D8F2-F21F-4524-A83F-A27032C348E0Q36233592-4EE7D161-093A-4851-AC95-AEA5410C93D4Q36237030-45128883-5896-4DED-AE6B-95FA668DBF24Q36410817-D4660365-99E3-402B-B922-3BF33E4646B8Q36411629-AE3ACCC8-91CC-46A9-A48B-FEF5FDC26747Q36416036-E0AD4582-D239-44FB-AC2D-A6CF0038AF9DQ36444962-4A9881D9-729D-44DA-B561-ACEDB334F851Q36445185-38B313A3-8EA1-48E5-AE13-0BC924BAD4D2Q36644359-47EDEC1A-0805-47BC-AF20-B7E53F526447Q36824454-8F6F1CDE-D6FB-4CDB-99C1-52DCFCB99949Q37023260-784085BB-1280-40C1-9277-9273D5A0D0E6Q37463586-68004667-CCFA-42B1-AA79-10262AC60CE0Q41460062-3A283B1D-1859-4C44-918E-F24C5A5BC182Q41761102-F397BCCA-E03C-436A-815F-1F50CF0DE873Q41992939-0FEB21D7-D40A-45F7-9CAE-A464DF27CE86Q42704011-032E86FC-1C55-4173-9337-B6AB946BB958Q42976855-D73B0D97-5786-4970-BF2B-2625093E5D0AQ49092156-053D0E28-759C-48D0-8164-0D437CC042AEQ50631011-3793D226-6526-4742-AE9B-C423B5185C15
P2860
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
A novel calcium current in dysgenic skeletal muscle.
@ast
A novel calcium current in dysgenic skeletal muscle.
@en
type
label
A novel calcium current in dysgenic skeletal muscle.
@ast
A novel calcium current in dysgenic skeletal muscle.
@en
prefLabel
A novel calcium current in dysgenic skeletal muscle.
@ast
A novel calcium current in dysgenic skeletal muscle.
@en
P356
P1476
A novel calcium current in dysgenic skeletal muscle.
@en
P2093
P304
P356
10.1085/JGP.94.3.429
P577
1989-09-01T00:00:00Z