Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels
about
Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic fibrosis transmembrane conductance regulator chloride channel poreSLC26A7 is a Cl- channel regulated by intracellular pHMouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting ductPerturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity.Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.Cystic fibrosis transmembrane conductance regulator (CFTR) anion binding as a probe of the poreMolecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Interaction between permeation and gating in a putative pore domain mutant in the cystic fibrosis transmembrane conductance regulator.Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.Endogenous surface expression of ΔF508-CFTR mediates cAMP-stimulated Cl(-) current in CFTR(ΔF508/ΔF508) pig thyroid epithelial cellsCystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions.Multi-Ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channelCystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patternsAnion permeation in Ca(2+)-activated Cl(-) channels.Molecular characterization of V59E NIS, a Na+/I- symporter mutant that causes congenital I- transport defect.Mutations at arginine 352 alter the pore architecture of CFTR.Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Cl- absorption across the thick ascending limb is not altered in cystic fibrosis mice. A role for a pseudo-CFTR Cl- channelIncreased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity.Managing the underlying cause of cystic fibrosis: a future role for potentiators and correctors.Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel.Architecture and functional properties of the CFTR channel pore.Protonation of lysine residues inverts cation/anion selectivity in a model channel.Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs.Evidence of a functional CFTR Cl(-) channel in adult alveolar epithelial cells.The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa.Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines.Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions.CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates.Cystic fibrosis transmembrane conductance regulator. Permeant ions find the pore.Patch clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channels activated by cyclic AMPIdentifying swelling-activated channels from ion selectivity patterns.Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.CFTR in K562 human leukemic cells.Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Structural and ionic determinants of 5-nitro-2-(3-phenylprophyl-amino)-benzoic acid block of the CFTR chloride channel.Cysteine substitutions reveal dual functions of the amino-terminal tail in cystic fibrosis transmembrane conductance regulator channel gating.
P2860
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P2860
Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Halide permeation in wild-type ...... ce regulator chloride channels
@ast
Halide permeation in wild-type ...... ce regulator chloride channels
@en
type
label
Halide permeation in wild-type ...... ce regulator chloride channels
@ast
Halide permeation in wild-type ...... ce regulator chloride channels
@en
prefLabel
Halide permeation in wild-type ...... ce regulator chloride channels
@ast
Halide permeation in wild-type ...... ce regulator chloride channels
@en
P2093
P2860
P356
P1476
Halide permeation in wild-type ...... ce regulator chloride channels
@en
P2093
J A Tabcharani
J W Hanrahan
P Linsdell
P2860
P304
P356
10.1085/JGP.110.4.341
P577
1997-10-01T00:00:00Z