Multi-Ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel
about
Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gatingMouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting ductDynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)Interaction between permeation and gating in a putative pore domain mutant in the cystic fibrosis transmembrane conductance regulator.Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical propertiesSubstrates of multidrug resistance-associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel.Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.Insight in eukaryotic ABC transporter function by mutation analysis.Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channelsPermeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions.Probing an open CFTR pore with organic anion blockersCystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patternsAnion permeation in Ca(2+)-activated Cl(-) channels.CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction.Synthetic nanopores as a test case for ion channel theories: the anomalous mole fraction effect without single filingThe anomalous mole fraction effect in calcium channels: a measure of preferential selectivityThe cystic fibrosis transmembrane conductance regulator in reproductive health and disease.CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lungMechanisms of bicarbonate secretion: lessons from the airways.Ivacaftor treatment of cystic fibrosis patients with the G551D mutation: a review of the evidence.Osmoregulation and excretion.Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.On the origin of asymmetric interactions between permeant anions and the cystic fibrosis transmembrane conductance regulator chloride channel pore.Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines.Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions.New views of multi-ion channels.Cystic fibrosis transmembrane conductance regulator. Permeant ions find the pore.Patch clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channels activated by cyclic AMPStable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.Structural and ionic determinants of 5-nitro-2-(3-phenylprophyl-amino)-benzoic acid block of the CFTR chloride channel.Identification of a region of strong discrimination in the pore of CFTR.Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.The role of the basolateral outwardly rectifying chloride channel in human airway epithelial anion secretion.Evidence that extracellular anions interact with a site outside the CFTR chloride channel pore to modify channel properties.Lumacaftor alone and combined with ivacaftor: preclinical and clinical trial experience of F508del CFTR correction.
P2860
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P2860
Multi-Ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@ast
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@en
type
label
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@ast
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@en
prefLabel
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@ast
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@en
P2093
P2860
P356
P1476
Multi-Ion mechanism for ion pe ...... nce regulator chloride channel
@en
P2093
J A Tabcharani
J W Hanrahan
P Linsdell
P2860
P304
P356
10.1085/JGP.110.4.365
P577
1997-10-01T00:00:00Z