Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits.
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Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channelsA novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channelsIdentification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channelsA role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels.Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinismMolecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10)ATP-sensitive potassium channels exhibit variance in the number of open channels below the limit predicted for identical and independent gatingSubunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanismN-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Molecular mechanism of pH sensing in KcsA potassium channels.A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium ChannelsEngineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channelMolecular biology of K(ATP) channels and implications for health and disease.Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivitySulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.ATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2.ATP sensitivity of ATP-sensitive K+ channels: role of the gamma phosphate group of ATP and the R50 residue of mouse Kir6.2.Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.Control of Kir channel gating by cytoplasmic domain interface interactionsAnti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-L-phenylalanine.Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity.Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel.Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels.Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels.
P2860
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P2860
Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@ast
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@en
type
label
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@ast
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@en
prefLabel
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@ast
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@en
P2093
P2860
P356
P1476
Stabilization of the activity ...... ween adjacent Kir6.2 subunits.
@en
P2093
Anne M Weinsoft
Show-Ling Shyng
Taiping Jia
Yu-Wen Lin
P2860
P304
P356
10.1085/JGP.200308822
P577
2003-08-01T00:00:00Z