Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition
about
How ATP inhibits the open K(ATP) channelRunning out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channelsATP interaction with the open state of the K(ATP) channel.Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytesNovel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces.Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactionsATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variantNucleotides and phospholipids compete for binding to the C terminus of KATP channels.KATP channels gated by intracellular nucleotides and phospholipids.Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATPMolecular basis for Kir6.2 channel inhibition by adenine nucleotides.Concerted gating mechanism underlying KATP channel inhibition by ATP.The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2Gating mechanism of KATP channels: function fits form.Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel.KATP Channels in the Cardiovascular System.Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels.The role of NH2-terminal positive charges in the activity of inward rectifier KATP channelsRegulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivationRegulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2.Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channelATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2.ATP sensitivity of ATP-sensitive K+ channels: role of the gamma phosphate group of ATP and the R50 residue of mouse Kir6.2.Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells.Reinterpreting the action of ATP analogs on K(ATP) channels.PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.Cytoplasmic vestibule of the weak inward rectifier Kir6.2 potassium channel.Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1.Phosphatidic acid stimulates cardiac KATP channels like phosphatidylinositols, but with novel gating kinetics.Compromised ATP binding as a mechanism of phosphoinositide modulation of ATP-sensitive K+ channels.
P2860
Q24648821-19E00017-D193-4F78-81AF-252CF3C8E386Q26744692-13B38D7A-79E5-4253-812D-6366459F2BC0Q28346280-273B2028-C253-4649-9000-EF3FBE3D8C13Q28366511-E17016C5-2241-41AA-A8F7-357B69234F8AQ28564824-8E502AC3-4E8F-4DE3-934B-E55581074E40Q28565185-78D37145-000A-456C-8345-EDA5C4CA9204Q31685657-7CCB95E5-7BE1-4B7D-964D-46E9DD18F101Q33702553-C697F679-3C6A-4397-AFC1-92D2F433F27DQ34014094-10657954-74E1-4105-BA82-8978E8CF6A32Q34039980-683BB5F7-7C52-44E0-8048-3A3A498A5026Q34093658-201BBE1F-CCA7-480A-ACA1-C1326405E6EBQ34166805-9F5DC473-83C3-4CA2-BDF7-12675FA45C3FQ34173659-D90EFBC3-BB68-4B5A-AB3C-55B6E33EDB45Q34180112-E7F809E2-A66B-45F9-8A44-8D60B77BACDEQ34185246-CA26310A-0095-4380-87FC-02ED4578600BQ34227906-42405C43-4B0F-47F7-BEA7-0D121580C34CQ34618893-90A67B87-D9B5-4602-8D2F-2D49562BC9FAQ35569293-7B9A7014-017D-4847-95C8-A4042D504E4EQ36412172-9DAC6209-E9D3-41C4-A616-E3B447AB4D2DQ36422478-A1BA8E0A-EDDD-4E62-8860-20A94A86D3E3Q36436285-354BBE0C-B47A-46EA-A282-BCE108DE1B6EQ36436454-6993754B-AD18-4C93-95BC-330A5B8A18EFQ36444702-B1DDB9E2-5E85-4AE3-9300-F65905013AB2Q36444788-4F8A3A77-194B-4965-9BBE-5CFC8D7FB437Q36445257-CAAB44BB-F610-4104-ACC2-00047852ED91Q36493543-8E4CD65B-852C-45AF-BCCC-97EDE428EABCQ40337022-ADFB1B0C-E31B-42CC-A81E-7FBCC145157AQ40372990-F76B3B4A-0B5A-4E5C-9121-5C5D406D63BBQ40387218-1EF03AF6-2B9A-41C8-9907-53F6E828E51AQ40754499-43F71115-6D10-43B4-8E83-75BE566CCD17Q41469020-9A2F5CA4-DF63-46C2-A68A-5237B92B0584Q42031021-E87F61C6-85CB-432D-95A4-5C7838166B35Q42411930-4B92ECB1-F00E-4E4C-8981-7FE1AD4DD192Q42616038-49403334-D1AE-4CE2-B402-0252625075EDQ43854347-9E25A68D-77B9-45F4-A62B-2A1572BC5D62Q43977779-A07557E9-5403-4DBC-95E4-C6A3DFFDC462Q44052261-9CF4322E-7DC8-43B2-B6AD-1C244FB04988Q44180806-42E95AAC-3AC3-457F-9372-F57CDC4F6462Q44185215-A988EEAC-5273-4120-8300-D1D27DB761D2Q44234594-A4964F7D-550C-4DD3-91BC-BD371BF76BB8
P2860
Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@ast
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@en
type
label
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@ast
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@en
prefLabel
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@ast
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@en
P2860
P356
P1476
Phosphoinositides decrease ATP ...... sm of ATP-sensitive inhibition
@en
P2093
P2860
P304
P356
10.1085/JGP.114.2.251
P577
1999-08-01T00:00:00Z