Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal.
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Sodium channel molecular conformations and antiarrhythmic drug affinityPrinciples of conduction and hydrophobic gating in K+ channelsThe role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channelsRemoval of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.A self-consistent approach for determining pairwise interactions that underlie channel activation.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.A shaker K+ channel with a miniature engineered voltage sensor.Molecular restraints in the permeation pathway of ion channels.Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.Hinge-bending motions in the pore domain of a bacterial voltage-gated sodium channelConstraints on voltage sensor movement in the shaker K+ channelImportant Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.K channel subconductance levels result from heteromeric pore conformations.Investigating the putative glycine hinge in Shaker potassium channel.Structure and anticipatory movements of the S6 gate in Kv channelshERG gating microdomains defined by S6 mutagenesis and molecular modeling.Structural basis of ion permeation gating in Slo2.1 K+ channels.Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels.Voltage-dependent gating of HERG potassium channels.Being flexible: the voltage-controllable activation gate of kv channels.Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1.SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5.Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels.Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel.Modulation of MthK potassium channel activity at the intracellular entrance to the pore.Where's the gate? Gating in the deep pore of the BK(Ca) channel.Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.A glimpse into the C-type-inactivated state for a Potassium Channel.Gating of the kir2.1 channel at the bundle crossing region by intracellular spermine and other cations.Structural insight into the transmembrane segments 3 and 4 of the hERG potassium channelGating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K channels
P2860
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P2860
Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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name
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@ast
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@en
type
label
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@ast
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@en
prefLabel
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@ast
Stabilizing the closed S6 gate ...... ication of a hydrophobic seal.
@en
P2860
P356
P1476
Stabilizing the closed S6 gate ...... fication of a hydrophobic seal
@en
P2093
Kenton J Swartz
Manana Sukhareva
P2860
P304
P356
10.1085/JGP.200409098
P577
2004-09-13T00:00:00Z