The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.
about
Notch receptor-ligand binding and activation: insights from molecular studiesStructural Insights into the Mechanism of Protein O-FucosylationFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsNotch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentThe canonical Notch signaling pathway: unfolding the activation mechanism.Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisitionEffects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes.O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammalsRole of glycosylation of Notch in developmentRole of glycans and glycosyltransferases in the regulation of Notch signalingFringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptorsGalectin-3 inhibits osteoblast differentiation through notch signaling.Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathwayO-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activationCharacterizing the glycome of the mammalian immune system.Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ions.Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactionsMultiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesisLunatic, Manic, and Radical Fringe Each Promote T and B Cell DevelopmentLunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo.In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1.Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice.Role of unusual O-glycans in intercellular signalingA Notch updated.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Roles of Pofut1 and O-fucose in mammalian Notch signaling.What Have We Learned from Glycosyltransferase Knockouts in Mice?The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.Unsweetened Notch leads to myeloproliferation.Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.Systemic localization of seven major types of carbohydrates on cell membranes by dSTORM imaging.Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.
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P2860
The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
The O-fucose glycan in the lig ...... enesis and T cell development.
@ast
The O-fucose glycan in the lig ...... enesis and T cell development.
@en
type
label
The O-fucose glycan in the lig ...... enesis and T cell development.
@ast
The O-fucose glycan in the lig ...... enesis and T cell development.
@en
prefLabel
The O-fucose glycan in the lig ...... enesis and T cell development.
@ast
The O-fucose glycan in the lig ...... enesis and T cell development.
@en
P2860
P356
P1476
The O-fucose glycan in the lig ...... enesis and T cell development.
@en
P2093
Changhui Ge
Pamela Stanley
P2860
P304
P356
10.1073/PNAS.0702846105
P407
P577
2008-01-28T00:00:00Z