Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
about
Transcription factor-mediated reprogramming toward hematopoietic stem cellsMEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.Reactive oxygen species in normal and tumor stem cells.MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion.Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac deathPbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells.FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell functionDpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila.Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells.Genome-wide histone state profiling of fibroblasts from the opossum, Monodelphis domestica, identifies the first marsupial-specific imprinted gene.Redox signaling in cardiac renewal.Autophagy and cell reprogramming.An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling.Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells.Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis.Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse.MEIS1 regulates early erythroid and megakaryocytic cell fate.The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesisMeis2 as a critical player in MN1-induced leukemia.MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.Mouse Models of Erythropoiesis and Associated Diseases.Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response.Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice
P2860
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P2860
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@ast
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@en
type
label
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@ast
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@en
prefLabel
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@ast
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@en
P2093
P2860
P50
P1433
P1476
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
@en
P2093
Ashish R Kumar
Elizabeth Thomas
Jason P Clark
Jayeeta Roychoudhury
Lino Tessarollo
Zeenath Unnisa
P2860
P304
P356
10.1182/BLOOD-2012-06-435800
P407
P577
2012-10-22T00:00:00Z