Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
about
Mechanisms of CFTR Folding at the Endoplasmic ReticulumMolecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic FibrosisCFTR and TMEM16A are separate but functionally related Cl- channelsDeletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperoneThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyIntegrated analysis of residue coevolution and protein structure in ABC transportersThe Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATEStructural Basis for Heavy Metal Detoxification by an Atm1-Type ABC ExporterCFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisThe primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domainA mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5pAllosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRJump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug TransporterThe endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.The cystic fibrosis transmembrane conductance regulator (CFTR) and its stabilityCodon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator.Development of CFTR StructureSmall-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathologyEvolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.Protein biophysics explains why highly abundant proteins evolve slowlyRegulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.Small molecule correctors of F508del-CFTR discovered by structure-based virtual screeningMolecular models of human P-glycoprotein in two different catalytic statesProbing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approachAsymmetric switching in a homodimeric ABC transporter: a simulation studyFolding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteinsEnhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Interplay between ER exit code and domain conformation in CFTR misprocessing and rescue.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapiesATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Decoding F508del misfolding in cystic fibrosis.Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTRCystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosisDual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement.Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.A chaperone trap contributes to the onset of cystic fibrosis.
P2860
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P2860
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Phenylalanine-508 mediates a c ...... assembly and channel function
@ast
Phenylalanine-508 mediates a c ...... assembly and channel function
@en
type
label
Phenylalanine-508 mediates a c ...... assembly and channel function
@ast
Phenylalanine-508 mediates a c ...... assembly and channel function
@en
prefLabel
Phenylalanine-508 mediates a c ...... assembly and channel function
@ast
Phenylalanine-508 mediates a c ...... assembly and channel function
@en
P2093
P2860
P356
P1476
Phenylalanine-508 mediates a c ...... assembly and channel function
@en
P2093
Andrei A Aleksandrov
John R Riordan
Liying Cui
Tamás Hegedus
P2860
P304
P356
10.1073/PNAS.0800254105
P407
P577
2008-02-27T00:00:00Z