Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr
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Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinasesToll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signalingSrc kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophilsFgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophilsPRAM-1 is required for optimal integrin-dependent neutrophil functionLy6 family proteins in neutrophil biologyCo-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signalingThe Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanineThe pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.TLR4-dependent lipopolysaccharide-induced shedding of tumor necrosis factor receptors in mouse bone marrow granulocytes.ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers.Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer ProgressionThe Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitmentEssential role for focal adhesion kinase in regulating stress hematopoiesis.Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4.Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.Effect of fluconazole on phagocytic response of polymorphonuclear leukocytes in a rat model of acute sepsis.Endotoxin antagonism: conceptual basis and therapeutic potential.Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injuryPro- and synbiotics to prevent sepsis in major surgery and severe emergencies.The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas.The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathwaysConstitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune responseNegative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.Src protein tyrosine kinase family and acute inflammatory responses.Nutrition of the critically ill — a 21st-century perspective.Aggressive management of surgical emergenciesMeprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.The diverse functions of Src family kinases in macrophages.Stimulation of the molecule 4-1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytesThe Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile InflammationSrc family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation.Nutrition of the critically ill - emphasis on liver and pancreasKinase activation in circulating cells: opportunities for biomarkers for diagnosis and therapeutic monitoring.
P2860
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P2860
Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@ast
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@en
type
label
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@ast
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@en
prefLabel
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@ast
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@en
P2860
P356
P1476
Resistance to endotoxic shock ...... Src-family kinases Hck and Fgr
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.13.7580
P407
P577
1998-06-01T00:00:00Z