Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice
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Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in miceLaser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombiDefective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.How the protease thrombin talks to cells.Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit.Special considerations in the evaluation of the hematology and hemostasis of mutant mice.Zebrafish as a model system for the study of hemostasis and thrombosis.Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domainGenetic sequence analysis of inherited bleeding diseases.Prothrombin structure: unanticipated features and opportunities.The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.Protease-activated receptors in the cardiovascular system.Modeling Disorders of Blood Coagulation in the Zebrafish.Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.Prothrombin deficiency results in embryonic and neonatal lethality in mice.A guide to murine coagulation factor structure, function, assays, and genetic alterations.Thrombin.The hemostasis system in murine atherosclerosis.Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.Reduced thrombin generation increases host susceptibility to group A streptococcal infectionMicroarray analysis of prothrombin knockdown in zebrafish.Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndromeHistorical perspective and future direction of coagulation research.Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyondModeling thrombin generation: plasma composition based approach.Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains.Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy.The Effects of the Contact Activation System on Hemorrhage.A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice.Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo.Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.Thrombin downregulates muscle acetylcholine receptors via an IP3 signaling pathway by activating its G-protein-coupled protease-activated receptor-1.A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.Thrombin reduces MuSK and acetylcholine receptor expression along with neuromuscular contact size in vitro.Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction.
P2860
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P2860
Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@ast
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@en
type
label
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@ast
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@en
prefLabel
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@ast
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@en
P2093
P2860
P356
P1476
Incomplete embryonic lethality ...... prothrombin deficiency in mice
@en
P2093
L A Westfield
P2860
P304
P356
10.1073/PNAS.95.13.7603
P407
P577
1998-06-01T00:00:00Z