Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania
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Plasticity of the Leishmania genome leading to gene copy number variations and drug resistanceThe secretory pathway of protists: spatial and functional organization and evolutionProteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis.The cloning by complementation of the pawn-A gene in ParameciumIdentification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major.Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.Biosynthesis of glycosylphosphatidylinositols in mammals and unicellular microbes.Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens.Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitroLeishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viabilityThe expression of biologically active human p53 in Leishmania cells: a novel eukaryotic system to produce recombinant proteinsLeishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.Surface Zn-proteinase as a molecule for defense of Leishmania mexicana amazonensis promastigotes against cytolysis inside macrophage phagolysosomes.Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutantThe roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation.Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.Transgenic Leishmania and the immune response to infectionThe role of phosphoglycans in Leishmania-sand fly interactionsThe LPG1 gene family of Leishmania major.Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hostsGfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O-glycan in Aspergillus nidulans and Aspergillus fumigatus.Profile of Stephen Beverley.Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact.Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence.Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana.Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.Golgi GDP-mannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters.Characterization of a ricin-resistant mutant of Leishmania donovani that expresses lipophosphoglycan.Biosynthesis of lipophosphoglycan from Leishmania major: solubilization and characterization of a (beta 1-3)-galactosyltransferase.Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania.Biosynthesis of galactomannans found in filamentous fungi belonging to Pezizomycotina.
P2860
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P2860
Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Isolation of virulence genes d ...... complementation of Leishmania
@ast
Isolation of virulence genes d ...... complementation of Leishmania
@en
type
label
Isolation of virulence genes d ...... complementation of Leishmania
@ast
Isolation of virulence genes d ...... complementation of Leishmania
@en
prefLabel
Isolation of virulence genes d ...... complementation of Leishmania
@ast
Isolation of virulence genes d ...... complementation of Leishmania
@en
P2093
P2860
P356
P1476
Isolation of virulence genes d ...... complementation of Leishmania
@en
P2093
A Descoteaux
L A Garraway
S M Beverley
P2860
P304
P356
10.1073/PNAS.90.18.8609
P407
P577
1993-09-01T00:00:00Z