Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.
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Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressGeneration of Leishmania hybrids by whole genomic DNA transformationProteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A.Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major featureLeishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viabilityNovel features of a PIWI-like protein homolog in the parasitic protozoan LeishmaniaMCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei.Protozomics: trypanosomatid parasite genetics comes of age.Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling.Target validation: linking target and chemical properties to desired product profileThe genetic toolbox for Leishmania parasitesRedirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutantCRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicanaThe LPG1 gene family of Leishmania major.A transposon toolkit for gene transfer and mutagenesis in protozoan parasites.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in LeishmaniaUnderstanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination.Shuttle mutagenesis and targeted disruption of a telomere-located essential gene of Leishmania.Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p.Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells.Characterization of the A2-A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection.
P2860
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P2860
Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Selection against the dihydrof ...... terations in Leishmania major.
@en
type
label
Selection against the dihydrof ...... terations in Leishmania major.
@en
prefLabel
Selection against the dihydrof ...... terations in Leishmania major.
@en
P2860
P356
P1476
Selection against the dihydrof ...... lterations in Leishmania major
@en
P2093
S M Beverley
P2860
P304
P356
10.1128/MCB.16.10.5655
P407
P577
1996-10-01T00:00:00Z