14-3-3 sigma positively regulates p53 and suppresses tumor growth. - Wikidata - awgldk - TriplyDB

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

http://www.wikidata.org/entity/Q36549508

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Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2 Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms Exportin 7 defines a novel general nuclear export pathway A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity 14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation.Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells The COP9 signalosome subunit 6 (CSN6): a potential oncogene Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis.14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β.The role and regulatory mechanism of 14-3-3 sigma in human breast cancer.14-3-3ζ as a prognostic marker and therapeutic target for cancer Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistance Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome.Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway Phosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes Dysregulation of the PI3K/Akt signaling pathway affects cell cycle and apoptosis of side population cells in nasopharyngeal carcinoma.CSN6 deregulation impairs genome integrity in a COP1-dependent pathway Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function Overexpression of 14-3-3σ counteracts tumorigenicity by positively regulating p73 in vivo Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells.

P2860

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P2860

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

http://www.wikidata.org/entity/Q36549508

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

@zh-cn

name

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

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14-3-3 sigma positively regulates p53 and suppresses tumor growth.

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type

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14-3-3 sigma positively regulates p53 and suppresses tumor growth.

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14-3-3 sigma positively regulates p53 and suppresses tumor growth.

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prefLabel

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

@ast

14-3-3 sigma positively regulates p53 and suppresses tumor growth.

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P356

MCB.23.20.7096-7107.2003

P1433

Molecular and Cellular Biology

P1476

14-3-3 sigma positively regulates p53 and suppresses tumor growth

@en

P2093

Chih-Hsin Chen

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Guillermina Lozano

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Heng-Yin Yang

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Yu-Ye Wen

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P2860

Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

BRCA1 regulates p53-dependent gene expression

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells

Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2

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7096-7107

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10.1128/MCB.23.20.7096-7107.2003

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230310

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