Targeted disruption of the gene for the PAK5 kinase in mice.
about
The emerging importance of group II PAKsPAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic propertiesGTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivoDeciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?Signaling, Regulation, and Specificity of the Type II p21-activated KinasesPAK4 kinase is essential for embryonic viability and for proper neuronal developmentFunctional deficits in PAK5, PAK6 and PAK5/PAK6 knockout micePAK signalling during the development and progression of cancerp21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic propertiesIdentification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell.Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.p21-activated kinase 7 is an oncogene in human osteosarcomaEfficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5Potential compensation among group I PAK members in hindlimb ischemia and wound healing.PAK1 as a therapeutic target.Copy number variations and primary open-angle glaucoma.A tale of two Paks.SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.Pak protein kinases and their role in cancer.PAK signaling in oncogenesis.High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma.Mouse models of PAK function.p21-Activated protein kinases and their emerging roles in glucose homeostasis.An oncogenic kinase: putting PAK5 forward.Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.Role for p21-activated kinase PAK4 in development of the mammalian heart.Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway.Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34.
P2860
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P2860
Targeted disruption of the gene for the PAK5 kinase in mice.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Targeted disruption of the gene for the PAK5 kinase in mice.
@ast
Targeted disruption of the gene for the PAK5 kinase in mice.
@en
type
label
Targeted disruption of the gene for the PAK5 kinase in mice.
@ast
Targeted disruption of the gene for the PAK5 kinase in mice.
@en
prefLabel
Targeted disruption of the gene for the PAK5 kinase in mice.
@ast
Targeted disruption of the gene for the PAK5 kinase in mice.
@en
P2860
P1476
Targeted disruption of the gene for the PAK5 kinase in mice.
@en
P2093
Audrey Minden
Xiaofan Li
P2860
P304
P356
10.1128/MCB.23.20.7134-7142.2003
P407
P577
2003-10-01T00:00:00Z