PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.
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The emerging importance of group II PAKsGroup II p21-activated kinases as therapeutic targets in gastrointestinal cancerPAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesionSmall-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growthType II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstratePAK as a therapeutic target in gastric cancerPAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasisOncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesisCharacterization of chlorpyrifos-induced apoptosis in placental cellsOxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation.Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic miceThe serine-threonine protein kinase PAK4 is dispensable in zebrafish: identification of a morpholino-generated pseudophenotypeMaternal pak4 expression is required for primitive myelopoiesis in zebrafishp21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patientsThe protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.Republished: tracing PAKs from GI inflammation to cancerSystems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model.Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines.Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in gliomaA novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.P21 activated kinases: structure, regulation, and functions.Tracing PAKs from GI inflammation to cancer.Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway.The secret life of kinases: functions beyond catalysisThe Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells.Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation.N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals.PAK4-6 in cancer and neuronal development.MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.The pak4 protein kinase in breast cancer.PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4.DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors.Role for p21-activated kinase PAK4 in development of the mammalian heart.Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.
P2860
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P2860
PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
PAK4 functions in tumor necros ...... D binding to the TNF receptor.
@en
type
label
PAK4 functions in tumor necros ...... D binding to the TNF receptor.
@en
prefLabel
PAK4 functions in tumor necros ...... D binding to the TNF receptor.
@en
P2860
P356
P1476
PAK4 functions in tumor necros ...... D binding to the TNF receptor.
@en
P2093
Audrey Minden
Xiaofan Li
P2860
P304
41192-41200
P356
10.1074/JBC.M506884200
P407
P577
2005-10-14T00:00:00Z