Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay - Wikidata - awgldk - TriplyDB

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

http://www.wikidata.org/entity/Q36550604

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta.A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Posttranscriptional control of gene expression in yeast.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiae Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing.Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila.mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.Nonsense-mediated decay of human HEXA mRNA.Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1 Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region The Upf-dependent decay of wild-type PPR1 mRNA depends on its 5'-UTR and first 92 ORF nucleotides Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae.Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants.Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia.Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.

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P2860

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

http://www.wikidata.org/entity/Q36550604

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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Molecular and Cellular Biology

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Identification and characteriz ...... n nonsense-mediated mRNA decay

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M J Ruiz-Echevarria

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S W Peltz

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S Zhang

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Y Quan

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P2860

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose

Transformation of intact yeast cells treated with alkali cations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis.

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript

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2231-2244

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4

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