Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase
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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationBiological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domainsRecent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemiasIdentification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinaseAxl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migrationOncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family membersGas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cellsGAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serumOverexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity.Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activationCross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase.Axl as a mediator of cellular growth and survivalTAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinomaTAM receptor deficiency affects adult hippocampal neurogenesis.Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-culturesMechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells.AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas.Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinomaNegative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cellsThe expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesotheliomaAxl-dependent signalling: a clinical update.The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages.Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family.TAM receptors in leukemia: expression, signaling, and therapeutic implications.The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic targetNormalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase.Biology of the TAM receptors.Higher expression of receptor tyrosine kinase Axl, and differential expression of its ligand, Gas6, predict poor survival in lung adenocarcinoma patients.
P2860
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P2860
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Differential activation of the ...... e Axl receptor tyrosine kinase
@ast
Differential activation of the ...... e Axl receptor tyrosine kinase
@en
type
label
Differential activation of the ...... e Axl receptor tyrosine kinase
@ast
Differential activation of the ...... e Axl receptor tyrosine kinase
@en
prefLabel
Differential activation of the ...... e Axl receptor tyrosine kinase
@ast
Differential activation of the ...... e Axl receptor tyrosine kinase
@en
P2093
P2860
P356
P1476
Differential activation of the ...... e Axl receptor tyrosine kinase
@en
P2093
A Burchert
L A Quilliam
P McCloskey
Y W Fridell
P2860
P304
P356
10.1128/MCB.16.1.135
P407
P577
1996-01-01T00:00:00Z