Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.
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The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cellsSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationSH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCFLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsProtein tyrosine phosphatases and the immune responseExpression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte developmentPhosphorylation site dynamics of early T-cell receptor signalingDevelopment of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck miceGreatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient miceHerpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes.Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis.Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage.The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.In vitro membrane reconstitution of the T-cell receptor proximal signaling network.Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanibThe oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation.Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.Interaction between CD45-AP and protein-tyrosine kinases involved in T cell receptor signaling.Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1.The role of CD45 and CD45-associated molecules in T cell activation.Reconstitution of interactions between protein-tyrosine phosphatase CD45 and tyrosine-protein kinase p56(lck) in nonlymphoid cells.HIV-1 infection is facilitated in T cells by decreasing p56lck protein tyrosine kinase activity.Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.Selected signalling proteins recruited to the T-cell receptor-CD3 complex.Feedback control of T-cell receptor activation.Overexpression of Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains induces cluster of differentiation 59-mediated apoptosis in Jurkat cells.Interactions of CD45-associated Protein with the Antigen Receptor Signaling Machinery in T-lymphocytes
P2860
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P2860
Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Mutational analysis of Lck in ...... horylation in kinase activity.
@ast
Mutational analysis of Lck in ...... horylation in kinase activity.
@en
type
label
Mutational analysis of Lck in ...... horylation in kinase activity.
@ast
Mutational analysis of Lck in ...... horylation in kinase activity.
@en
prefLabel
Mutational analysis of Lck in ...... horylation in kinase activity.
@ast
Mutational analysis of Lck in ...... horylation in kinase activity.
@en
P2093
P2860
P356
P1476
Mutational analysis of Lck in ...... horylation in kinase activity.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.9.4996
P407
P577
1996-09-01T00:00:00Z