A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
about
The RAG1 N-terminal domain is an E3 ubiquitin ligaseRecombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemAutoubiquitylation of the V(D)J recombinase protein RAG1A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingDual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.The RAG proteins in V(D)J recombination: more than just a nuclease.Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine modelN-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Evidence for Ku70/Ku80 association with full-length RAG1.RAG-dependent primary immunodeficiencies.A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.The roles of the RAG1 and RAG2 "non-core" regions in V(D)J recombination and lymphocyte development.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins.Correlation between recombinase activating gene 1 ubiquitin ligase activity and V(D)J recombination.
P2860
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P2860
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@ast
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@en
type
label
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@ast
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@en
prefLabel
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@ast
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@en
P2093
P2860
P356
P1476
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
@en
P2093
C J McMahan
D G Schatz
E Spanopoulou
M J Difilippantonio
P2860
P304
P356
10.1128/MCB.17.8.4544
P407
P577
1997-08-01T00:00:00Z