Expression and V(D)J recombination activity of mutated RAG-1 proteins
about
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposonsThe RAG1 N-terminal domain is an E3 ubiquitin ligaseVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityAmino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processRAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.The response to and repair of RAG-mediated DNA double-strand breaksMolluscan mobile elements similar to the vertebrate Recombination-Activating GenesAutoubiquitylation of the V(D)J recombinase protein RAG1Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinaseA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsMapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.Crystal structure of the V(D)J recombinase RAG1-RAG2Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.The origins of the Rag genes--from transposition to V(D)J recombination.Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombinationDistinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthInitiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.The RAG proteins in V(D)J recombination: more than just a nuclease.Mobilization of RAG-generated signal ends by transposition and insertion in vivoXR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.Identification and characterization of a gain-of-function RAG-1 mutant.Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.The C-terminal portion of RAG2 protects against transposition in vitroKu80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferaseThe architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationOverlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.Requirements for DNA hairpin formation by RAG1/2
P2860
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P2860
Expression and V(D)J recombination activity of mutated RAG-1 proteins
description
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1993
@ast
im Dezember 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/12/11)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/12/11)
@nl
наукова стаття, опублікована в грудні 1993
@uk
مقالة علمية (نشرت في 11-12-1993)
@ar
name
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@ast
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@en
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@nl
type
label
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@ast
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@en
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@nl
prefLabel
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@ast
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@en
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@nl
P2093
P2860
P356
P1476
Expression and V(D)J recombination activity of mutated RAG-1 proteins
@en
P2093
P2860
P304
P356
10.1093/NAR/21.24.5644
P407
P577
1993-12-01T00:00:00Z