Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor. - Wikidata - awgldk - TriplyDB

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.

http://www.wikidata.org/entity/Q36571961

about

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements A new recombinant factor VIII: from genetics to clinical use.Issues and challenges of subvisible and submicron particulate analysis in protein solutions High-throughput analysis of concentration-dependent antibody self-association.Freezing-induced perturbation of tertiary structure of a monoclonal antibody Buffer-dependent fragmentation of a humanized full-length monoclonal antibody.Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy Amyloid-beta fibrillogenesis seeded by interface-induced peptide misfolding and self-assembly Conformational and aggregation properties of a PEGylated alanine-rich polypeptide Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities.Determination of second virial coefficient of proteins using a dual-detector cell for simultaneous measurement of scattered light intensity and concentration in SEC-HPLC.Non-native aggregation of recombinant human granulocyte-colony stimulating factor under simulated process stress conditions.Improved drug-like properties of therapeutic proteins by directed evolution.Role of anisotropic interactions for proteins and patchy nanoparticles.Structure based descriptors for the estimation of colloidal interactions and protein aggregation propensities Crucial role of nonspecific interactions in amyloid nucleation.Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides Patterns of protein protein interactions in salt solutions and implications for protein crystallization.Aggregation of granulocyte-colony stimulating factor in vitro involves a conformationally altered monomeric state.Effects of glycosylation on the stability of protein pharmaceuticals.Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and in vivo bioavailability.Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization.Structure and thermodynamics of colloidal protein cluster formation: comparison of square-well and simple dipolar models.Lysine and arginine content of proteins: computational analysis suggests a new tool for solubility design.High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability.The use of self-interaction chromatography in stable formulation and crystallization of proteins.Aggregates in monoclonal antibody manufacturing processes.A multiscale view of therapeutic protein aggregation: a colloid science perspective.Study on the effect of solution conditions on heat induced-aggregation of human alpha interferon.Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant.Exploiting sequence and stability information for directing nanobody stability engineering.Preparation of hydrogel embedded polymer-growth factor conjugated nanoparticles as a diabetic wound dressing.Experimental and Computational Analysis of Protein Stabilization by Gly-to-d-Ala Substitution: A Convolution of Native State and Unfolded State Effects.Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions.Nonspecific shielding of unfavorable electrostatic intramolecular interactions in the erythropoietin native-state increase conformational stability and limit non-native aggregation.Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.

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P2860

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.

http://www.wikidata.org/entity/Q36571961

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2003 nî lūn-bûn

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Protein Science

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Roles of conformational stabil ...... yte colony-stimulating factor.

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Brent S Kendrick

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Byeong S Chang

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Eva Y Chi

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John F Carpenter

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Sampathkumar Krishnan

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P2860

The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors

Protein crystallization by design: chymotrypsinogen without precipitants

Determination and analysis of urea and guanidine hydrochloride denaturation curves

Use of glycerol, polyols and other protein structure stabilizing agents in protein crystallization.

Distance dependence and salt sensitivity of pairwise, coulombic interactions in a protein

Linear extrapolation method of analyzing solvent denaturation curves.

Molecular origins of osmotic second virial coefficients of proteins.

Protein interactions in solution characterized by light and neutron scattering: comparison of lysozyme and chymotrypsinogen

Effect of glycerol on the interactions and solubility of bovine pancreatic trypsin inhibitor

Interactions and aggregation of apoferritin molecules in solution: effects of added electrolytes.

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12

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