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Adsorption of monoclonal antibodies to glass microparticles.Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models.Freezing-induced perturbation of tertiary structure of a monoclonal antibodyOxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants.Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.Buffer-dependent fragmentation of a humanized full-length monoclonal antibody.Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administrationRational design of stable lyophilized protein formulations: theory and practice.Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation.Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteinsSurfactant Effects on Particle Generation in Antibody Formulations in Pre-filled SyringesInfluence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine.Precipitation of a monoclonal antibody by soluble tungstenMonoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studiesAggregation of a monoclonal antibody induced by adsorption to stainless steelEffects of surfaces and leachables on the stability of biopharmaceuticals.Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.Preformulation study of highly purified inactivated polio vaccine, serotype 3.Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions.Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study.Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure.Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution.Common excipients impair detection of protein aggregates during sedimentation velocity analytical ultracentrifugation.A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions.Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulationsHigh-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.High-pressure refolding of bikunin: efficacy and thermodynamics.Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products.Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions.Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin.Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
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name
Theodore W Randolph
@en
type
label
Theodore W Randolph
@en
prefLabel
Theodore W Randolph
@en