about
Children's Oncology Group's 2013 blueprint for research: bone tumorsModeling initiation of Ewing sarcoma in human neural crest cells.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisTargeted Therapy of Ewing's Sarcoma.Abundance, arrangement, and function of sequence motifs in the chicken promoters.Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.EWS-FLI1 employs an E2F switch to drive target gene expression.Advances in sarcoma genomics and new therapeutic targets.Pediatric cancer epigenome and the influence of folateMolecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma CellsEpigenetic changes in pediatric solid tumors: promising new targets.The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcomaTargeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancerMicroRNA function and dysregulation in bone tumors: the evidence to dateGene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma.Oxidative stress and therapeutic opportunities: focus on the Ewing's sarcoma family of tumors.Ewing sarcoma protein: a key player in human cancerBlocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma.Structure-function based molecular relationships in Ewing's sarcoma.microRNA and Bone Cancer.EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration.The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genesInhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducersFunctional Interactions in Transcription and Splicing of Ewing’s Sarcoma
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
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2010年學術文章
@zh-hant
name
Downstream EWS/FLI1 - upstream Ewing's sarcoma
@en
Downstream EWS/FLI1 - upstream Ewing's sarcoma.
@nl
type
label
Downstream EWS/FLI1 - upstream Ewing's sarcoma
@en
Downstream EWS/FLI1 - upstream Ewing's sarcoma.
@nl
prefLabel
Downstream EWS/FLI1 - upstream Ewing's sarcoma
@en
Downstream EWS/FLI1 - upstream Ewing's sarcoma.
@nl
P2860
P356
P1433
P1476
Downstream EWS/FLI1 - upstream Ewing's sarcoma
@en
P2093
Heinrich Kovar
P2860
P2888
P356
10.1186/GM129
P577
2010-01-28T00:00:00Z
P5875
P6179
1024900638