Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery - Wikidata - awgldk - TriplyDB

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

http://www.wikidata.org/entity/Q36621898

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Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe Activation of the ATR kinase by the RPA-binding protein ETAA1 ETAA1 acts at stalled replication forks to maintain genome integrity The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism DNA2 drives processing and restart of reversed replication forks in human cells.Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex Chromatin remodeling factors Isw2 and Ino80 regulate checkpoint activity and chromatin structure in S phase.Yet another job for Dna2: Checkpoint activation.Genetic Regulation of Dna2 Localization During the DNA Damage Response.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response Sharpening the ends for repair: mechanisms and regulation of DNA resection.Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Clamping down on mammalian meiosis.Genomic analysis of primordial dwarfism reveals novel disease genes.Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.MCM10: one tool for all-Integrity, maintenance and damage control.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast The essential kinase ATR: ensuring faithful duplication of a challenging genome.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.Replication checkpoint: tuning and coordination of replication forks in s phase.Four pillars of the S-phase checkpoint.GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.The elemental role of iron in DNA synthesis and repair.Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.

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Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

http://www.wikidata.org/entity/Q36621898

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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name

Lagging strand maturation fact ...... heckpoint initiation machinery

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Lagging strand maturation fact ...... heckpoint initiation machinery

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Lagging strand maturation fact ...... heckpoint initiation machinery

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Lagging strand maturation fact ...... heckpoint initiation machinery

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Genes & Development

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Lagging strand maturation fact ...... heckpoint initiation machinery

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Peter M Burgers

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Sandeep Kumar

http://www.w3.org/2001/XMLSchema#string

P2860

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

Polymerase dynamics at the eukaryotic DNA replication fork

DNA end resection: many nucleases make light work

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

A mutant with a defect in telomere elongation leads to senescence in yeast.

Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth

Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.

The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

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313-321

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scholarly article

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10.1101/GAD.204750.112

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3

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27

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3576516

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