Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
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Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significanceBroad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integraseIdentification of a nucleotide binding site in HIV-1 integraseRetroviral DNA IntegrationRequirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids.Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.A dynamic model of HIV integrase inhibition and drug resistance.Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.A chimeric Ty3/Moloney murine leukemia virus integrase protein is active in vivo.Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylationMoloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells.Functional RT and IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein.Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer.Human immunodeficiency virus type 1 (HIV-1) integrase: resistance to diketo acid integrase inhibitors impairs HIV-1 replication and integration and confers cross-resistance to L-chicoric acid.Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.Inserting a nuclear targeting signal into a replication-competent Moloney murine leukemia virus affects viral export and is not sufficient for cell cycle-independent infection.Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genomeHuman immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cellsThe central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivityMultiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replicationIntegration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.Coordinated disintegration reactions mediated by Moloney murine leukemia virus integrase.Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease.Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivityStructure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein.Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.Methods for gene transfer to the central nervous system.Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription.Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis.
P2860
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P2860
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@ast
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@en
type
label
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@ast
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@en
prefLabel
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@ast
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
@en
P2093
P2860
P1433
P1476
Genetic analysis of the human immunodeficiency virus type 1 integrase protein
@en
P2093
P2860
P304
P407
P577
1994-03-01T00:00:00Z