p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. - Wikidata - awgldk - TriplyDB

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.

http://www.wikidata.org/entity/Q36645083

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The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition Transforming pathways activated by the v-Abl tyrosine kinase Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth Activation and activities of the p53 tumour suppressor protein The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV Nucleolar Arf sequesters Mdm2 and activates p53 Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.The p14ARF alternate reading frame protein enhances DNA binding of topoisomerase I by interacting with the serine 506-phosphorylated core domain.p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice.Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells.Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice.Signaling pathways activated by oncogenic forms of Abl tyrosine kinase.Modeling malignant melanoma in mice: pathogenesis and maintenance.Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes.Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain.Mink cell focus-forming murine leukemia virus killing of mink cells involves apoptosis and superinfection Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages.Human ARF protein interacts with topoisomerase I and stimulates its activity.p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells.p53 deficiency increases transformation by v-Abl and rescues the ability of a C-terminally truncated v-Abl mutant to induce pre-B lymphoma in vivo.Decreased virus population diversity in p53-null mice infected with weakly oncogenic Abelson virus.Role of p14(ARF) in replicative and induced senescence of human fibroblasts.ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.Malignancy: Tumor Suppressor Gene Aberrations in Acute Myelogenous Leukemia.NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop.

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P2860

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.

http://www.wikidata.org/entity/Q36645083

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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1998年论文

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1998年论文

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name

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

@ast

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

@en

type

label

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

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p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

@en

prefLabel

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

@ast

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

p19(Arf) induces p53-dependent ...... ted pre-B cell transformation.

@en

P2093

A Radfar

http://www.w3.org/2001/XMLSchema#string

H W Lee

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I Unnikrishnan

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N Rosenberg

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R A DePinho

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P2860

Growth suppression by p16ink4 requires functional retinoblastoma protein

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Mdm2 promotes the rapid degradation of p53

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

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13194-13199

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10.1073/PNAS.95.22.13194

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23757

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