Multiple pathways contribute to the pathogenesis of Huntington disease.
about
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingIntracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseasesPluripotent stem cells models for Huntington's disease: prospects and challengesGenome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's diseaseComprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocyclineSynaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.Monkey hybrid stem cells develop cellular features of Huntington's disease.Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease miceNetwork organization of the huntingtin proteomic interactome in mammalian brain.Reprogramming Huntington monkey skin cells into pluripotent stem cellsAged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.Evaluating the SERCA2 and VEGF mRNAs as Potential Molecular Biomarkers of the Onset and Progression in Huntington's DiseaseMitochondrial medicine for aging and neurodegenerative diseasesThe Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic AnalysesMitochondria as a therapeutic target for aging and neurodegenerative diseases.Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's diseaseImpaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease.The gene coding for PGC-1alpha modifies age at onset in Huntington's DiseaseDifferential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.Nanoscale studies link amyloid maturity with polyglutamine diseases onset.Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.Mitochondrial structural and functional dynamics in Huntington's disease.Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protectionImpaired mitochondrial trafficking in Huntington's disease.Polyglutamine toxicity in non-neuronal cells.Proteasomal dysfunction in aging and Huntington disease.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington's Disease.Calcium signaling and neurodegenerative diseases.Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.Calcium signaling and neurodegeneration.Adult neural progenitor cells from Huntington's disease mouse brain exhibit increased proliferation and migration due to enhanced calcium and ROS signals.Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein.Progress in developing transgenic monkey model for Huntington's disease.RNAi-based therapies for Huntington’s disease: delivery challenges and opportunities
P2860
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P2860
Multiple pathways contribute to the pathogenesis of Huntington disease.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Multiple pathways contribute to the pathogenesis of Huntington disease.
@ast
Multiple pathways contribute to the pathogenesis of Huntington disease.
@en
type
label
Multiple pathways contribute to the pathogenesis of Huntington disease.
@ast
Multiple pathways contribute to the pathogenesis of Huntington disease.
@en
prefLabel
Multiple pathways contribute to the pathogenesis of Huntington disease.
@ast
Multiple pathways contribute to the pathogenesis of Huntington disease.
@en
P2860
P356
P1476
Multiple pathways contribute to the pathogenesis of Huntington disease.
@en
P2093
Xiao-Jiang Li
P2860
P2888
P356
10.1186/1750-1326-1-19
P577
2006-12-16T00:00:00Z
P5875
P6179
1050498794