Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins
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The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcriptionComparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABINSpecific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complexTwo discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cellsTax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets.Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activationMechanisms of T-cell activation by human T-cell lymphotropic virus type I.An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker.Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.Evidence for NF-kappaB- and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts.NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent mannerInactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4).The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300Human T-cell leukemia virus type 1 expressing nonoverlapping tax and rex genes replicates and immortalizes primary human T lymphocytes but fails to replicate and persist in vivo.The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerizationPhysical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma proteinDifferential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeatHTLV-I Tax self-association in optimal trans-activation function.Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisSpecific interaction of HTLV tax protein and a human type IV neuronal intermediate filament proteinDistinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors.Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathyThe amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein.Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin specklesInteraction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat.The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.Mutational analysis of human T-cell leukemia virus type 2 Tax.Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element.Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factorsInteraction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA
P2860
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P2860
Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins
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1992 nî lūn-bûn
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1992年の論文
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1992年論文
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1992年論文
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1992年論文
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1992年論文
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1992年論文
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1992年论文
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1992年论文
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name
Mutational analysis of human T ...... rmined with 47 mutant proteins
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Mutational analysis of human T ...... rmined with 47 mutant proteins
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type
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Mutational analysis of human T ...... rmined with 47 mutant proteins
@ast
Mutational analysis of human T ...... rmined with 47 mutant proteins
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prefLabel
Mutational analysis of human T ...... rmined with 47 mutant proteins
@ast
Mutational analysis of human T ...... rmined with 47 mutant proteins
@en
P2860
P1433
P1476
Mutational analysis of human T ...... rmined with 47 mutant proteins
@en
P2093
P2860
P304
P407
P577
1992-12-01T00:00:00Z