Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
about
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsDetermination of ubiquitin fitness landscapes under different chemical stresses in a classroom settingViewing protein fitness landscapes through a next-gen lens.Residue proximity information and protein model discrimination using saturation-suppressor mutagenesisDetection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated serverMolecular Effects of Concentrated Solutes on Protein Hydration, Dynamics, and Electrostatics.Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeastSoftware for the analysis and visualization of deep mutational scanning data.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis DataHigh-resolution network biology: connecting sequence with function.A comprehensive, high-resolution map of a gene's fitness landscapePivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encodedAn experimentally determined evolutionary model dramatically improves phylogenetic fit.An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologsEvolutionary biochemistry: revealing the historical and physical causes of protein properties.Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.A systematic survey of an intragenic epistatic landscape.Latent effects of Hsp90 mutants revealed at reduced expression levels.Massively parallel single-amino-acid mutagenesisDeep mutational scanning: a new style of protein scienceHow structural and physicochemical determinants shape sequence constraints in a functional enzymeHigh-resolution sequence-function mapping of full-length proteins.Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsRole of a non-canonical surface of Rad6 in ubiquitin conjugating activity.Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell CultureA high throughput mutagenic analysis of yeast sumo structure and function.Predicting the impact of Lynch syndrome-causing missense mutations from structural calculationsLinkage-specific conformational ensembles of non-canonical polyubiquitin chainsUbSRD: The Ubiquitin Structural Relational Database.Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.Triallelic Population Genomics for Inferring Correlated Fitness Effects of Same Site Nonsynonymous Mutations.Local fitness landscape of the green fluorescent protein.Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein.Contemporary, yeast-based approaches to understanding human genetic variation.Ubiquitin utilizes an acidic surface patch to alter chromatin structure.A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environmentsAlanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function.
P2860
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P2860
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@ast
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@en
type
label
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@ast
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@en
prefLabel
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@ast
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@en
P2093
P2860
P1476
Analyses of the effects of all ubiquitin point mutants on yeast growth rate.
@en
P2093
Benjamin P Roscoe
David Fushman
Kelly M Thayer
Konstantin B Zeldovich
P2860
P304
P356
10.1016/J.JMB.2013.01.032
P407
P50
P577
2013-01-30T00:00:00Z