Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.
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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EDengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibitedMechanism and regulation of eukaryotic protein synthesisAn isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegansRapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translationEpigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferationTargeting the translational machinery as a novel treatment strategy for hematologic malignanciesNovel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation.Complex formation between potyvirus VPg and translation eukaryotic initiation factor 4E correlates with virus infectivityhnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation.Dysregulating IRES-dependent translation contributes to overexpression of oncogenic Aurora A Kinase.Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.Targeting the eIF4F translation initiation complex: a critical nexus for cancer developmentSpecific isoforms of translation initiation factor 4GI show differences in translational activityDifferential Requirements for eIF4E Dose in Normal Development and CancerEmerging therapeutics targeting mRNA translationContribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.mTOR coordinates protein synthesis, mitochondrial activity and proliferation.Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E.The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational controlThe oncogene eIF4E: using biochemical insights to target cancer.Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancerRapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation.Targeting translation dependence in cancerTargeting Mnks for cancer therapy.Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.Protein kinase C isoenzymes: divergence in signal transduction?Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins.Translation initiation on the insulin-like growth factor II leader 1 is developmentally regulated.Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression.Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells.Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos.Beyond molecular tumor heterogeneity: protein synthesis takes control.Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture.
P2860
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P2860
Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@ast
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@en
type
label
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@ast
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@en
prefLabel
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@ast
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@en
P2093
P2860
P1476
Expression of antisense RNA ag ...... the p220 component of eIF-4F.
@en
P2093
A De Benedetti
C Rinker-Schaeffer
R E Rhoads
S Joshi-Barve
P2860
P304
P407
P577
1991-11-01T00:00:00Z