Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
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Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vectorAnalysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Transforming potential of the adenovirus type 5 E4orf3 protein.Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexAdenovirus early region 4 stimulates mRNA accumulation via 5' introns.An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.The adenovirus E4 11 k protein binds and relocalizes the cytoplasmic P-body component Ddx6 to aggresomes.Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids.Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisAdenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodiesControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityPhosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activityHuman adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein.Sequences required for coordinate induction of adeno-associated virus p19 and p40 promoters by Rep proteinDefective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cellsRUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisRedundant control of adenovirus late gene expression by early region 4Intranuclear location of the adenovirus type 5 E1B 55-kilodalton protein.A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression.Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex.Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA.Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation.The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha.
P2860
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P2860
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@ast
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@en
type
label
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@ast
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@en
prefLabel
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@ast
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@en
P2860
P1433
P1476
Adenovirus early region 4 is essential for normal stability of late nuclear RNAs
@en
P2093
P2860
P304
P407
P577
1989-02-01T00:00:00Z