A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia. - Wikidata - awgldk - TriplyDB

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.

http://www.wikidata.org/entity/Q36781396

about

Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.PML protein isoforms and the RBCC/TRIM motif Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.In vivo analysis of the molecular genetics of acute promyelocytic leukemia.APL, a model disease for cancer therapies?Translocations of the RARalpha gene in acute promyelocytic leukemia.Transcriptional regulation in acute promyelocytic leukemia.The theory of APL.Molecular rearrangements and morphology in thyroid cancer.Retinoid target genes in acute promyelocytic leukemia.Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2 Acute promyelocytic leukemia: where does it stem from?Hematopoiesis and retinoids: development and disease.Genetic and biological subgroups of low-stage follicular thyroid cancer Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells.Animal models of acute myelogenous leukaemia - development, application and future perspectives.The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma.Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice New insights into the role of PML in tumour suppression.Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.Notch signaling in acute promyelocytic leukemia Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation.Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.Commonly dysregulated genes in murine APL cells.Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.Creating a transloxation. Engineering interchromosomal translocations in the mouse.Haploinsufficiency for tumor suppression: the hazards of being single and living a long time.Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha.Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia.

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P2860

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.

http://www.wikidata.org/entity/Q36781396

description

1999 nî lūn-bûn

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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1999年论文

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1999年论文

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name

A bcr-3 isoform of RARalpha-PM ...... acute promyelocytic leukemia.

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type

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A bcr-3 isoform of RARalpha-PM ...... acute promyelocytic leukemia.

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prefLabel

A bcr-3 isoform of RARalpha-PM ...... acute promyelocytic leukemia.

@en

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Proceedings of the National Academy of Sciences of the United States of America

P1476

A bcr-3 isoform of RARalpha-PM ...... acute promyelocytic leukemia.

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P2093

A K Kurichety

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J L Grisolano

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J L Pollock

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P G Pelicci

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P Westervelt

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T J Ley

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P2860

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice

The retinoblastoma protein and cell cycle control

Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the M.R.C. ATRA trial. M.R.C. Adult Leukaemia Working Party

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

Role of PML in cell growth and the retinoic acid pathway

Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia.

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.

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15103-15108

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