Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling
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TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemiaPI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Bruton's tyrosine kinase (BTK) inhibitors in clinical trials.Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaBTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia.Preclinical modeling of novel therapeutics in chronic lymphocytic leukemia: the tools of the tradeA role for IRF4 in the development of CLL.A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cellsDepletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo.Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic LeukemiaCell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling.Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.Inhibition of reactive oxygen species limits expansion of chronic lymphocytic leukemia cells.Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome.Pharmacodynamics and proteomic analysis of acalabrutinib therapy: similarity of on-target effects to ibrutinib and rationale for combination therapy.Role of Bruton's tyrosine kinase in B cells and malignancies.Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency
P2860
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P2860
Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling
description
2013 nî lūn-bûn
@nan
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
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2013年论文
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name
Autoantigen can promote progre ...... nced B-cell receptor signaling
@en
type
label
Autoantigen can promote progre ...... nced B-cell receptor signaling
@en
prefLabel
Autoantigen can promote progre ...... nced B-cell receptor signaling
@en
P2093
P2860
P356
P1476
Autoantigen can promote progre ...... nced B-cell receptor signaling
@en
P2093
Franak Batliwalla
Nichol E Holodick
Nicholas Chiorazzi
Shih-Shih Chen
Sophia Yancopoulos
Thomas L Rothstein
Xiao-Jie Yan
P2860
P304
P356
10.1073/PNAS.1300616110
P407
P577
2013-04-02T00:00:00Z