Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
about
Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brainHuman APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer modelIntraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms.CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer's diseaseAntioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivoAPOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice.Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases.β-Amyloid peptides and amyloid plaques in Alzheimer's disease.Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical EvidenceAlzheimer's disease: experimental models and reality.1MeTIQ provides protection against Aβ-induced reduction of surface expression of synaptic proteins and inhibits H₂O₂-induced oxidative stress in primary hippocampal neurons.Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models.Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology.Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease
P2860
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P2860
Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Blocking the interaction betwe ...... inhibits synaptic degeneration
@ast
Blocking the interaction betwe ...... inhibits synaptic degeneration
@en
type
label
Blocking the interaction betwe ...... inhibits synaptic degeneration
@ast
Blocking the interaction betwe ...... inhibits synaptic degeneration
@en
prefLabel
Blocking the interaction betwe ...... inhibits synaptic degeneration
@ast
Blocking the interaction betwe ...... inhibits synaptic degeneration
@en
P2093
P2860
P1476
Blocking the interaction betwe ...... inhibits synaptic degeneration
@en
P2093
Ayodeji A Asuni
Joanna Pankiewicz
Jungsu Kim
Magdalena A Kuszczyk
Maitea Guridi
Malgorzata Duszczyk
Martin J Sadowski
Patrick M Sullivan
Sandrine Sanchez
P2860
P304
P356
10.1016/J.AJPATH.2013.01.034
P407
P577
2013-03-13T00:00:00Z