Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis.
about
Transgenic cell lines for detection of animal virusesInhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection.Herpes simplex virus DNA replication: the UL9 gene encodes an origin-binding proteinIn vitro processing of herpes simplex virus type 1 DNA replication intermediates by the viral alkaline nuclease, UL12Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein.Helicase motif Ia is involved in single-strand DNA-binding and helicase activities of the herpes simplex virus type 1 origin-binding protein, UL9.Existence of transdominant and potentiating mutants of UL9, the herpes simplex virus type 1 origin-binding protein, suggests that levels of UL9 protein may be regulated during infection.Properties of the novel herpes simplex virus type 1 origin binding protein, OBPCDirect interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer.Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer templateHelicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity.The UL5 gene of herpes simplex virus type 1: isolation of a lacZ insertion mutant and association of the UL5 gene product with other members of the helicase-primase complex.Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.Mutations in a herpes simplex virus type 1 origin that inhibit interaction with origin-binding protein also inhibit DNA replication.The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for functionConstruction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis.The UL8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization.Herpes simplex virus type 1 gene products required for DNA replication: identification and overexpression.Herpes simplex virus type 1 DNA synthesis requires the product of the UL8 gene: isolation and characterization of an ICP6::lacZ insertion mutation.Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis.The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.An ICP6::lacZ insertional mutagen is used to demonstrate that the UL52 gene of herpes simplex virus type 1 is required for virus growth and DNA synthesisNucleoprotein complex formed between herpes simplex virus UL9 protein and the origin of DNA replication: inter- and intramolecular interactionsBinding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication.ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.Expression of human cytomegalovirus UL36 and UL37 genes is required for viral DNA replication.Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesis.A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome.Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA-dependent ATPase and DNA helicase activities.Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication.
P2860
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P2860
Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Isolation and characterization ...... ective in viral DNA synthesis.
@en
type
label
Isolation and characterization ...... ective in viral DNA synthesis.
@en
prefLabel
Isolation and characterization ...... ective in viral DNA synthesis.
@en
P2093
P2860
P1433
P1476
Isolation and characterization ...... ective in viral DNA synthesis.
@en
P2093
E P Carmichael
M J Kosovsky
S K Weller
P2860
P407
P577
1988-01-01T00:00:00Z