Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. - Wikidata - awgldk - TriplyDB

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

http://www.wikidata.org/entity/Q36830063

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Size matters in activation/inhibition of ligand-gated ion channels Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism Neuronal nicotinic receptors: from protein structure to function An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function.Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.Tightening of the ATP-binding sites induces the opening of P2X receptor channels High throughput electrophysiology with Xenopus oocytes Allosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channel Genistein directly inhibits native and recombinant NMDA receptors.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors Acetylcholine receptors and myasthenia.Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein.The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein.α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces.Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.The use of electrophysiology to improve understanding of drug-receptor interactions.Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method Nicotine activates immature "silent" connections in the developing hippocampus.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick alpha7 nicotinic receptor.Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeable The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction.Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors Co-expression of the neuronal alpha7 and L247T alpha7 mutant subunits yields hybrid nicotinic receptors with properties of both wild-type alpha7 and alpha7 mutant homomeric receptors Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

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P2860

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

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Proceedings of the National Academy of Sciences of the United States of America

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Unconventional pharmacology of ...... mutated in the channel domain.

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Ballivet M

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Bertrand D

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Changeux JP

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Devillers-Thiéry A

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Galzi JL

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P2860

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor

Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

Cloning by functional expression of a member of the glutamate receptor family.

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain.

Explorations of the nicotinic acetylcholine receptor.

Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture.

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1261-1265

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