Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.
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Size matters in activation/inhibition of ligand-gated ion channelsGinseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptorsCrystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of AntagonismNeuronal nicotinic receptors: from protein structure to functionAn insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsyThe atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channelsStable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonistsDifferential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in ratsMice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birthMutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function.Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutationsStructural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.Tightening of the ATP-binding sites induces the opening of P2X receptor channelsHigh throughput electrophysiology with Xenopus oocytesAllosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channelGenistein directly inhibits native and recombinant NMDA receptors.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsAcetylcholine receptors and myasthenia.Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein.The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein.α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces.Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.The use of electrophysiology to improve understanding of drug-receptor interactions.Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility methodNicotine activates immature "silent" connections in the developing hippocampus.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane siteSelective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick alpha7 nicotinic receptor.Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptorStructurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightnessImplications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeableThe functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction.Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticityThe influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptorsCo-expression of the neuronal alpha7 and L247T alpha7 mutant subunits yields hybrid nicotinic receptors with properties of both wild-type alpha7 and alpha7 mutant homomeric receptorsSingle amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
P2860
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P2860
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Unconventional pharmacology of ...... mutated in the channel domain.
@en
type
label
Unconventional pharmacology of ...... mutated in the channel domain.
@en
prefLabel
Unconventional pharmacology of ...... mutated in the channel domain.
@en
P2093
P2860
P356
P1476
Unconventional pharmacology of ...... mutated in the channel domain.
@en
P2093
Ballivet M
Bertrand D
Bertrand S
Changeux JP
Devillers-Thiéry A
P2860
P304
P356
10.1073/PNAS.89.4.1261
P407
P577
1992-02-01T00:00:00Z