Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120. - Wikidata - awgldk - TriplyDB

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120.

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120.

http://www.wikidata.org/entity/Q36839845

about

Click chemistry in peptide-based drug design Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120.Covalent conjugation of a peptide triazole to HIV-1 gp120 enables intramolecular binding site occupancy The active core in a triazole peptide dual-site antagonist of HIV-1 gp120.Mechanism of multivalent nanoparticle encounter with HIV-1 for potency enhancement of peptide triazole virus inactivation.Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors.Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.Short Communication: Inhibition of DC-SIGN-Mediated HIV-1 Infection by Complementary Actions of Dendritic Cell Receptor Antagonists and Env-Targeting Virus Inactivators.HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter.Peptide triazole inactivators of HIV-1: how do they work and what is their potential?Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity.A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption Non-natural peptide triazole antagonists of HIV-1 envelope gp120.10 years of click chemistry: synthesis and applications of ferrocene-derived triazoles.Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.Cell-free HIV-1 virucidal action by modified peptide triazole inhibitors of Env gp120.Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions.Ferrocene-substituted dithio-o-carborane isomers: influence on the native conformation of myoglobin protein.Survey of the 2009 commercial optical biosensor literature.Synthesis and antioxidant evaluation of enantiomerically pure bis-(1,2,3-triazolylmethyl)amino esters from modified α-amino acids.

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P2860

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120.

http://www.wikidata.org/entity/Q36839845

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Introducing metallocene into a ...... viral potency for HIV-1 gp120.

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Introducing metallocene into a ...... viral potency for HIV-1 gp120.

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Ferit Tuzer

http://www.w3.org/2001/XMLSchema#string

Fred C Krebs

http://www.w3.org/2001/XMLSchema#string

Hosahudya Gopi

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Irwin M Chaiken

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Isaac Zentner

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Karyn McFadden

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Navneet Jawanda

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Sabine Baxter

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Sandya Ajith

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Simon Cocklin

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P2860

Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.

Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library.

Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation

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169-174

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scholarly article

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10.1002/JMR.892

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2

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22

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5352239

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18498083

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3652662

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