Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.
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Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophyCollapse of proteostasis represents an early molecular event in Caenorhabditis elegans agingFour decades of neurodegenerative disease research: how far we have come!The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradationUbr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.Spg5 protein regulates the proteasome in quiescence.Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.K63 polyubiquitination is a new modulator of the oxidative stress responseVCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFDReversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathwaysDichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerioThe p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteinsActivation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain.Out with the old, in with the new? Comparing methods for measuring protein degradation.Cdc48 and cofactors Npl4-Ufd1 are important for G1 progression during heat stress by maintaining cell wall integrity in Saccharomyces cerevisiae.Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132Characterization of the Brain 26S Proteasome and its Interacting ProteinsUbiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsThe N-end rule pathway and regulation by proteolysisElevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.The eukaryotic translation elongation Factor 1Bgamma has a non-guanine nucleotide exchange factor role in protein metabolismExpression and distribution of the class III ubiquitin-conjugating enzymes in the retinaMuscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell linesReversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat StressSoil metatranscriptomics for mining eukaryotic heavy metal resistance genes.Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.Ubiquitination of newly synthesized proteins at the ribosome.Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation.A novel approach to recovery of function of mutant proteins by slowing down translation.The core regulation module of stress-responsive regulatory networks in yeastMechanisms for countering oxidative stress and damage in retinal pigment epithelium.Vulnerability of newly synthesized proteins to proteostasis stress.Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.Stressing the ubiquitin-proteasome system.Heat shock proteins: keys to healthy ageing?Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases.Re-examining class-I presentation and the DRiP hypothesisOxidative stress and the ubiquitin proteolytic system in age-related macular degeneration.
P2860
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P2860
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Heat shock and oxygen radicals ...... of newly synthesized proteins.
@en
type
label
Heat shock and oxygen radicals ...... of newly synthesized proteins.
@en
prefLabel
Heat shock and oxygen radicals ...... of newly synthesized proteins.
@en
P2860
P356
P1476
Heat shock and oxygen radicals ...... of newly synthesized proteins.
@en
P2093
Alfred L Goldberg
Balasubrahmanyam Medicherla
P2860
P304
P356
10.1083/JCB.200803022
P407
P577
2008-08-01T00:00:00Z