Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
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Acute Myeloid Leukemia: A Concise ReviewStructural Basis of Targeting the Exportin CRM1 in CancerNovel Prognostic and Therapeutic Mutations in Acute Myeloid LeukemiaMitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating DrugsA Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the NucleusGenomic and molecular characterization of esophageal squamous cell carcinomaTargeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.KPT-330 has antitumour activity against non-small cell lung cancer.Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.Atomic basis of CRM1-cargo recognition, release and inhibitionProtein mislocalization: mechanisms, functions and clinical applications in cancer.KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsSINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agentsNucleo-cytoplasmic transport as a therapeutic target of cancerSmall molecule inhibitors in acute myeloid leukemia: from the bench to the clinicshRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compoundsExpression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma.Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapyCombination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia.ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver.Preclinical activity of selinexor, an inhibitor of XPO1, in sarcomaPreclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia.Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways.Allosteric control of the exportin CRM1 unraveled by crystal structure analysis.Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.Targeted therapy of acute myeloid leukemia.Selective inhibitors of nuclear export (SINE) in hematological malignancies.A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation.
P2860
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P2860
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
@en
type
label
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
@en
prefLabel
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
@en
P2093
P2860
P1433
P1476
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
@en
P2093
Archana Dilip
Jared K Burks
Kensuke Kojima
Kevin R Coombes
Michael Kauffman
Nianxiang Zhang
R Eric Davis
Seshagiri Duvvuri
Sharon Shacham
P2860
P304
P356
10.1182/BLOOD-2012-08-447581
P407
P577
2013-04-05T00:00:00Z