Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
about
The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanismsAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsLigand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELICActivation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonistsCholinergic interneurons are differentially distributed in the human striatumMechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein familyEnergy and structure of the M2 helix in acetylcholine receptor-channel gating.Gating of acetylcholine receptor channels: brownian motion across a broad transition state.Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-capConformational changes in the nicotinic acetylcholine receptor during gating and desensitizationA gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptorThe dissociation of acetylcholine from open nicotinic receptor channelsThe nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.Molecular dynamics simulations of C2F6 effects on gramicidin A: implications of the mechanisms of general anesthesia.Theoretical studies of the M2 transmembrane segment of the glycine receptor: models of the open pore structure and current-voltage characteristics.Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.Pharmacology of structural changes at the GABA(A) receptor transmitter binding site.Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility methodStructural effects of quinacrine binding in the open channel of the acetylcholine receptor.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightnessLife at the top: the transition state of AChR gating.Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC.Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities.Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor.Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker.The location of a closed channel gate in the GABAA receptor channel.Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonistThe extracellular linker of muscle acetylcholine receptor channels is a gating control element.Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening.Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants.Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor.The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.Acute alcohol action and desensitization of ligand-gated ion channels.Myasthenia in acquired neuromyotoniaModeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms.
P2860
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P2860
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
@en
type
label
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
@en
prefLabel
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
@en
P2860
P356
P1476
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
@en
P2093
P2860
P304
P356
10.1085/JGP.112.2.181
P577
1998-08-01T00:00:00Z