Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. - Wikidata - awgldk - TriplyDB

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

http://www.wikidata.org/entity/Q36852549

about

The transcription factor p53: not a repressor, solely an activator Role of pregnane X receptor in chemotherapeutic treatment Targeting xenobiotic receptors PXR and CAR in human diseases PXR variants: the impact on drug metabolism and therapeutic responses Tissue-specific regulation of pregnane X receptor in cancer development and therapy.PXR interaction with p53: a meeting of two masters Human pregnane X receptor compromises the function of p53 and promotes malignant transformation Pregnane X Receptor and Cancer: Context-Specificity is Key.Identification and characterization of phosphorylation sites within the pregnane X receptor protein.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.PXR: More Than Just a Master Xenobiotic Receptor.

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P2860

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

http://www.wikidata.org/entity/Q36852549

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

@zh-cn

name

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

@en

type

label

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

@en

prefLabel

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

@en

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Molecular Pharmacology

P1476

Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.

@en

P2093

Ayesha Elias

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Jing Wu

http://www.w3.org/2001/XMLSchema#string

Taosheng Chen

http://www.w3.org/2001/XMLSchema#string

P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

Oncogenic forms of p53 inhibit p53-regulated gene expression

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

p53 mutations in human cancers

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

P304

1229-1236

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scholarly article

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10.1124/MOL.113.085092

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6

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83

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2013-03-27T00:00:00Z

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236088191

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23536728

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