SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.
about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionExtended wakefulness: compromised metabolics in and degeneration of locus ceruleus neuronsSIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activitySIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressShort-term calorie restriction enhances skeletal muscle stem cell functionMitophagy plays a central role in mitochondrial ageingSirt1 and the MitochondriaRedox regulation of FoxO transcription factorsForever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegenerationSirtuin 1 and sirtuin 3: physiological modulators of metabolismRole of sirtuins in ischemia-reperfusion injurySIRT3 regulates progression and development of diseases of aging.Sirtuins in hematological aging and malignancyExploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activityC. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stressFunction of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeMitochondrial stress signaling promotes cellular adaptationsSirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesisMitochondrial localization of the forkhead box class O transcription factor FOXO3a in brainFoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscleFOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling.Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoformsSIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in miceLiver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.SirT3 regulates the mitochondrial unfolded protein response.Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress.Mitochondrial acetylation and diseases of aging.Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning.Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.Angiotensin receptors as determinants of life span.Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression.AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSODThe human sirtuin family: evolutionary divergences and functions.Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
P2860
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P2860
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
SIRT3 interacts with the daf-1 ...... O3a dependent gene expression.
@en
type
label
SIRT3 interacts with the daf-1 ...... O3a dependent gene expression.
@en
prefLabel
SIRT3 interacts with the daf-1 ...... O3a dependent gene expression.
@en
P2093
P2860
P356
P1476
SIRT3 interacts with the daf-1 ...... O3a dependent gene expression.
@en
P2093
Bong-Hyun Ahn
Chu-Xia Deng
David Gius
Douglas R Spitz
Hyun-Seok Kim
J Daniel Pennington
Jaime Leclerc
Kheem S Bisht
Kristi Muldoon Jacobs
Lunching Sun
P2860
P304
P356
10.7150/IJBS.4.291
P407
P577
2008-09-05T00:00:00Z